# Clinical Reasoning Database Status — RC4

## What changed
RC4 activates a populated starter knowledge library inside the patient analysis workflow.

## Active populated starter library
- 51 medication records
- Generic/brand/alias recognition
- Pharmacologic class
- Therapeutic class
- Active review domains
- Safety/review cues
- Therapeutic substitution candidates
- Medication matches surfaced in the captured-patient analysis

## Validation boundary
The library is active for real workflow testing, matching, UI review, MedRec/substitution visibility, and captured-patient review cue generation.

It is **not** final clinical publication content. Each dosing, contraindication, interaction, renal adjustment, compatibility, stability, tube/crush, and monitoring claim still requires source-specific evidence with exact section/locator and owner review.

## Source strategy
- DailyMed SPL and openFDA labeling for official label sections
- RxNorm/RxClass for identity, brands, aliases, and drug-class relationships
- PubMed and uploaded PDFs for domains not reliably completed by labeling alone

## Active file
`ClinicalReasoningDatabase/active/active-knowledge-starter.json`
